An individual's health, genetic, or environmental-exposure data, placed in an online repository, creates a valuable shared resource that can accelerate biomedical research and even open opportunities for crowd-sourcing discoveries by members of the public. But these data become “immortalized” in ways that may create lasting risk as well as benefit. Once shared on the Internet, the data are difficult or impossible to redact, and identities may be revealed by a process called data linkage, in which online data sets are matched (...) to each other. Reidentification, the process of associating an individual's name with data that were considered deidentified, poses risks such as insurance or employment discrimination, social stigma, and breach of the promises often made in informed-consent documents. At the same time, re-ID poses risks to researchers and indeed to the future of science, should re-ID end up undermining the trust and participation of potential research participants. The ethical challenges of online data sharing are heightened as so-called big data becomes an increasingly important research tool and driver of new research structures. Big data is shifting research to include large numbers of researchers and institutions as well as large numbers of participants providing diverse types of data, so the participants’ consent relationship is no longer with a person or even a research institution. In addition, consent is further transformed because big data analysis often begins with descriptive inquiry and generation of a hypothesis, and the research questions cannot be clearly defined at the outset and may be unforeseeable over the long term. In this article, we consider how expanded data sharing poses new challenges, illustrated by genomics and the transition to new models of consent. We draw on the experiences of participants in an open data platform—the Personal Genome Project—to allow study participants to contribute their voices to inform ethical consent practices and protocol reviews for big-data research. (shrink)

Soren Kierkegaard is widely held to be the founder of existentialism. His faith is ironic, playful and passionate, and he wrote like a novelist. This book brilliantly explains his life and thought.

I argue that a standard formulation of hinge epistemology is host to epistemic relativism and show that two leading hinge approaches (Coliva’s acceptance account and Pritchard’s nondoxastic account) are vulnerable to a form of incommensurability that leads to relativism. Building on both accounts, I introduce a new, minimally epistemic conception of hinges that avoids epistemic relativism and rationally resolves hinge disagreements. According to my proposed account, putative cases of epistemic incommensurability are rationally resolvable: hinges are propositions that are the objects (...) of our belief-like attitudes and are rationally revisable in virtue of our overarching commitment to avoid systematic deception in our epistemic practices. (shrink)

I argue against the Standard View of ignorance, according to which ignorance is defined as equivalent to lack of knowledge, that cases of environmental epistemic luck, though entailing lack of knowledge, do not necessarily entail ignorance. In support of my argument, I contend that in cases of environmental luck an agent retains what I call epistemic access to the relevant fact by successfully exercising her epistemic agency and that ignorance and non-ignorance, contrary to what the Standard View predicts, are not (...) modal in the sense that knowledge is. After responding to objections, I conclude by sketching an alternative account of ignorance centered on the notions of epistemic access and epistemic agency. (shrink)

This paper argues that there are instances in which tobacco control litigation is strengthening the justiciability of the right to health and health-related rights. This is happening in different parts of the world, but in particular in Latin America. In part this is because, to a certain extent, tobacco control litigation based on fundamental rights overcomes the traditional arguments against economic, social and cultural rights adjudication: the anti-democratic argument, the lack of technical competency argument, the problem of the misallocation of (...) scarce public resources and the problem of the implementation of judicial decisions. As we analyzed in this paper, tobacco control cases based on fundamental rights are allowing courts to elaborate on broader standards of judicial adjudication of social rights, e.g., expand notions of standing, progressive realization, and state obligations enshrined in the right to health. Key to this judicial trend is the Framework Convention on Tobacco Control, which provides a legal standard — supported by scientific evidence — defining concrete measures states should take to address the tobacco epidemic, and thus giving content to the right to health as it relates to tobacco control. (shrink)

There is perhaps no area of law that so effectively protects human health and thereby advances the right to the highest attainable standard of health, as tobacco control. Globally, tobacco is responsible for 1 in 10 adult deaths, and is on track to kill 10 million people per year, mostly in developing countries, representing a US$200 billion drain on the global economy. Yet experience in recent decades has shown that a range of tobacco control measures, such as comprehensive bans on (...) smoking in public places, tobacco taxes, and limits on tobacco advertising, can greatly reduce smoking prevalence. These measures have slowly curtailed the epidemic, despite strong opposition from various sectors led by the tobacco industry. It is fitting that tobacco control is the focus of a recent, widely ratified global treaty and of increasing national litigation, often directly linked to countries’ human rights commitments. (shrink)

Recognizing the influence crises have in shaping global governance nowadays, the present work explores the possible contribution of human development thinking countering the perverse effects of shock-driven responses to major emergencies. This is done by focusing on contributions by Sen, Dreze, Haq and Stewart related to famines, violent conflict and the idea of human security, analyzed using a selection of four criteria, namely, describing the position of crisis inside human development thinking, issues of modeling and measurement, the stance toward agency, (...) and the actors gathered around the discourse. After strengths and weaknesses are considered, the article suggests a tangential involvement through other human concepts, so human development ideas do not get muddled by the logic of shocks and fulfill the great responsibility of helping us avoid the many shortfalls of a security-obsessed view of humanity. (shrink)

This article introduces a symposium that aims to identify and critically assess the legal strategies of the tobacco, alcohol, and food and beverage industries which rest on freedom of expression arguments.

Drawing on detailed German panel data, we find that gifts and inheritances substantially increase households’ private pension savings in accounts which are costly or impossible to withdraw prematurely. Back-of-the-envelope calculations suggest that the average difference in bequest-induced private pension savings between heirs and non-heirs accrues to more than 40,000 euros at retirement, and that it would take an average non-heir household roughly 14 years to match this gap. The sizable difference in private pension savings between heirs and non-heirs persists when (...) we take into account other investments of heirs and non-heirs potentially intended to provide for old age. Our evidence supports the impact of gifts and inheritances on inequality in retirement wealth highlighted in recent research on intergenerational justice. We discuss several policy implications of our results. Online appendix. (shrink)

An introduction to propositional logical and first-order logic.

This article argues that the decision by the Columbian high court to totally ban the advertising and promotion of tobacco products is sound and could indeed be applied to other types of harmful products.

This article provides a critical and philosophical assessment of arguments invoked for and against the constitutional protection of commercial expression and the regulation of commercial speech with a focus on the commercialization of unhealthy food products.

Dorian Gray pays a hefty price for years of sin and vice in this completely unabridged edition of The Picture of Dorian Gray.

Research indicates the essentiality of dignity as a vital component for quality of life, reconfirming the emphasis on dignity preservation in the international code of nursing ethics. Applying Noblit and Hare’s meta-ethnography, the aim of the study was to develop a theory model by synthesizing 10 qualitative articles from various cultural contexts, exploring nurse and allied healthcare professional perception/practice concerning dignity-preserving dementia care. “Advocating the person’s autonomy and integrity,” which involves “having compassion for the person,” “confirming the person’s worthiness and (...) sense of self,” and “creating a humane and purposeful environment,” was identified as a primary foundation for dignity-preserving dementia care. “Balancing individual choices among persons no longer able to make sound decisions, against the duty of making choices on behalf of the person,” which involves “persuasion” and/or “mild restraint,” was considered a crucial aspect in certain situations. “Sheltering human worth—remembering those who forget” was identified as a comprehensive motive and core value within dignity-preserving dementia care. (shrink)

Nuclear intermolecular duplexes appear to be a general feature of nucleated cells. Most of these duplexes are formed between large RNA as well as between large and small RNA molecules. A significant portion of the large molecules belong to a special class of RNA that is restricted to the nucleus and, therefore, not designated for export. These molecules are assembled with proteins and form a structure of a higher order. The possibility that these molecules and a set of small nuclear (...) RNAs are components of a complex machine, “the transportosome”, which functions in nucleocytoplasmic traffic, is discussed. (shrink)

Whereas intersectionality presents a fruitful framework for theoretical and empirical research, some of its fundamental features present great confusion. The term ‘intersectionality’ and its metaphor of the crossroads seem to reproduce what it aims to avoid: conceiving categories as separate. Despite the attempts for developing new metaphors that illustrate the mutual constitution relation among categories, gender, race or class keep being imagined as discrete units that intersect, mix or combine. Here we identify two main problems in metaphors: the lack of (...) differentiation between positions and effects and the problem of reification. We then present a new metaphor that overcomes these two problems: a basket of apples. We argue that considering social positions as the diverse properties of different apples avoids reification by considering categories as properties and not as objects themselves, and at the same time it allows us to think about the effects dimension from a plural and contextual approach. With this shift, we propose a reframing of the discussion in debates on intersectionality theory on the relation among categories, their in/separability and fragmentation. (shrink)

Resumen La cuestión de la relación entre ciencia y fe ha adquirido nuevo vigor en los comienzos del siglo, cuando, tras años de especialización y separación fragmentaria de los saberes, que conducían a la esquizofrenia cultural del cognoscente, se empieza a percibir de manera cada vez más nítida la necesidad de su integración para dar cuenta de la multidimensionalidad de lo real. Tras poner de manifiesto la aparente tensión entre cultura y trascendencia como realidades que conviven en el ser humano, (...) se rastrea la posibilidad que Panikkar propone de una ciencia que, sin eliminarse a sí misma, sin cancelar la mediación que ella misma constituye ni despojarse de sus maneras y métodos propios, sin siquiera abandonar el plano de la pura inmanencia, reconoce en él lo divino: la infinita trascendencia del cuerpo -su carácter siempre abierto al misterio- y su infinita inmanencia -su profundidad insondable-. Esto tiene lugar en la forma concreta que el autor propone de una teofisica, de modo que con ella no ocurre algo semejante a lo que Wittgenstein indica respecto a la escalera de la que, una vez arriba -lograda la significación de lo Absoluto- puedo desprenderme, sino que, en ella, la escalera -la dimensión física- se conserva y se supera.The issue of the relationship between science and faith has acquired greater relevance since the beginning of the century, time in which, after years of specialization and fragmentation of human knowledge, which have led to a cultural schizophrenia of the knower, there is a growing awareness of the need to integrate both to account for a multidimensional reality. After noticing the apparent tension between culture and the divine as realities that coexist in human beings, it is examined Panikkar’s proposal of a science that, without eliminating itself, without cancelling the mediation that it constitutes, nor divesting itself from its own methods, not even without abandoning immanence, recognizes in itself the divine: the infinite transcendence of the body -its character always open to mystery- and its infinite immanence -its unfathomable depth-. This corresponds to the author’s theophysics, so that, in it, it does not happen something similar to what Wittgenstein indicates about the ladder of which one can get rid once up -when the significance of the divine has been attained-, but in it the ladder -the physical dimension- is preserved and surpassed. (shrink)

This text aims to rethink educational activity inspired by the thought of the philosopher Ignacio Ellacuría, in what we have synthesised as a pedagogy of poverty. This should be understood as a pedagogy that, in the neoliberal context of Western societies, takes poverty as its motor—its efficient cause—and as its essence or fundamental structure—its formal cause –, in the duality of dimensions of its genitive. It is concretised in what is presented as Problem-Based Service-Learning (PB-SL). Through specific pedagogical guidelines for (...) implementing this methodology, this study indicates how the teaching action can show the learner what is immediate, what is not constructed, what consciousness does not establish but rather encounters: reality—weak, limited, imperfect, needy; in short, poor—as a problem and, in its deficiency and insufficiency, as a task towards which the subject has a responsibility. This reveals the fundamental anthropological structure to the learner: its intrinsic relational character—its reality as a being-in-a-suffering-world, who lives-with and lives-to save the needy who share its humanity. It is then possible to perceive the scale of the ultimate aim of PB-SL: the need to create the social conditions for a praxis that enables a dignification of reality. (shrink)

Predictive coding models of brain processing propose that top-down cortical signals promote efficient neural signaling by carrying predictions about incoming sensory information. These “priors” serve to constrain bottom-up signal propagation where prediction errors are carried via feedforward mechanisms. Depression, traditionally viewed as a disorder characterized by negative cognitive biases, is associated with disrupted reward prediction error encoding and signaling. Accumulating evidence also suggests that depression is characterized by impaired local and long-range prediction signaling across multiple sensory domains. This review highlights (...) the electrophysiological and neuroimaging evidence for disrupted predictive processing in depression. The discussion is framed around the manner in which disrupted generative predictions about the sensorium could lead to depressive symptomatology, including anhedonia and negative bias. In particular, the review focuses on studies of sensory deviance detection and reward processing, highlighting research evidence for both disrupted generative predictions and prediction error signaling in depression. The role of the monoaminergic and glutamatergic systems in predictive coding processes is also discussed. This review provides a novel framework for understanding depression using predictive coding principles and establishes a foundational roadmap for potential future research. (shrink)

The present article explores the epistemological conditions of intercultural encounters. Based on an analysis of Raimon Panikkar's intercultural hermeneutics, we argue that intercultural encounters cannot take place adequately when they are based on purely rhetorical rationality or rational persuasion. We point to the limitations of grounding intercultural relationships on dialectical dialogue and, therefore, of educating them by simply enhancing discursive capacities. We underline the need for other epistemological conditions that should be fostered in order to move forward on the path (...) to actual interculturality. These can be summarised by what Panikkar calls "conversion", an epistemic framework of love—personal relationality, that goes beyond objectifying rationality—for the communication between (culturally different) subjects. We conclude that the culturally diverse human condition refers to being encountered and being understood on a level that is not merely logical or linguistic. What can be understood of a person with another cultural background goes beyond what can be comprehended by logical rationality or captured by veritative judgements about objects. In other words, in intercultural encounters, ontological, rather than merely logical truth is at stake, which means that the presence of the other can lead to experiences of meaning: it reveals a being that calls for conversion. Conversion demands an ontic action on the part of the subject, not merely an epistemological one, that cancels the violence that rational persuasion might entail. (shrink)

Resumen: El presente trabajo analiza si los Sistemas de apoyo a la decisión (DSSs) y otros asistentes para su uso, como las Reflection machines o los Personal Assistants that Learn (PAL), contribuyen de hecho a una mejora cognitiva, como habitualmente se tiende a asumir. Es decir, se examina si su potencial para expandir e impulsar la acción de las facultades cognoscitivas se ve efectivamente actualizado y, en consecuencia, si sirven para reafirmar el sentido capacitante de la IA y la extensión (...) de la agencia del sujeto a través de ella. Para ello, se pone de manifiesto que el diseño y aplicación de estos sistemas están mediados por una comprensión del conocimiento que actúa a modo de marco que limita sus posibilidades de mejorar las capacidades cognoscitivas humanas. Se analizan las condiciones en que la mejora cognitiva es posible a través del uso de estos sistemas, que remiten a una aproximación integradora que no tiene en cuenta solo el factor tecnológico, sino que repara en cómo, en su uso, intervienen factores gnoseológicos, así como psicológicos y sociológicos, que median en la capacidad efectiva de estos sistemas de ampliar las facultades de conocimiento, y de los que las tecnologías se sirven para ejercer su influencia. Abstract: The present article questions whether Decision Support Systems (DSSs) and other assistants for their use, such as Reflection machines or Personal Assistants that Learn (PAL), do in fact contribute to cognitive enhancement, as it is usually taken for granted. In other words, it is analysed whether their potential to effectively expand or augment cognitive capacities is actualised and, therefore, if the capabilities and the agency of the person appear in fact extended through artificial intelligence. For that purpose, it is highlighted that the design and implementation of AI systems are dependent on a certain understanding of human knowledge that acts as a framework that limits their actual capacity to enhance the cognitive faculties of the mind. The conditions under which this cognitive enhancement is possible through these systems are analysed and require an integrative approach that not only takes technology into account but realises that, in its use, gnoseological, as well as psychological and sociological factors are involved and mediate in the actual capacity of these systems to extend cognitive functions. These factors are also crucial for these technologies to exert their influence. (shrink)

Mood disorders, including major depressive disorder and bipolar disorder, are highly prevalent, frequently disabling, and sometimes deadly. Additional research and more effective medications are desperately needed, but clinical trials research in mood disorders is fraught with ethical issues. Although many authors have discussed these issues, most do so from a theoretical viewpoint. This manuscript uses available empirical data to inform a discussion of the primary ethical issues raised in mood disorders research. These include issues of consent and decision-making capacity, including (...) patients’ motivations for participating in research. We also address drug withdrawals, placebo controls, and the overall safety of research. Finally, we examine the extant literature for studies discussing potential indirect benefits of clinical trials research to participants. Taken together, the evidence suggests that clinical trials research incorporating drug withdrawals and placebo controls can be conducted safely and ethically, even in patients with severe or treatment-resistant mood disorders. In fact, given the dearth of effective treatment options for this population, it is our opinion that a moral imperative exists to extend the offer of research participation to severely ill or treatment-resistant groups. (shrink)

Insofar as development implies economic growth, the term 'sustainable development' appears to some as a contradiction in terms. However, such conclusions still lack a thorough examination of the conceptual structure of the two terms between which there is a purported contradiction. In order to address this issue, the present paper scrutinises some of the assumptions which underwrite the ideologies of sustainability and of development. It is argued that there are key assumptions which both ideas have in common, and that sustainable (...) development is thus perfectly coherent on a conceptual level. It is alternatives which retain either term (such as 'sustainable degrowth') that are embroiled in paradox. The paper then examines two concepts for criticising the ideology of economic growth in other terms: dépense and conviviality. It is argued that the latter is preferable to the former for the purpose of developing post-sustainable critiques of growth. (shrink)

Whereas intersectionality presents a fruitful framework for theoretical and empirical research, some of its fundamental features present great confusion. The term ‘intersectionality’ and its metaphor of the crossroads seem to reproduce what it aims to avoid: conceiving categories as separate. Despite the attempts for developing new metaphors that illustrate the mutual constitution relation among categories, gender, race or class keep being imagined as discrete units that intersect, mix or combine. Here we identify two main problems in metaphors: the lack of (...) differentiation between positions and effects and the problem of reification. We then present a new metaphor that overcomes these two problems: a basket of apples. We argue that considering social positions as the diverse properties of different apples avoids reification by considering categories as properties and not as objects themselves, and at the same time it allows us to think about the effects dimension from a plural and contextual approach. With this shift, we propose a reframing of the discussion in debates on intersectionality theory on the relation among categories, their in/separability and fragmentation. (shrink)